Mapping Complex Traits; identify a susceptibility locus custom essay

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Select a complex disease and review the methodology that has been used to identify a susceptibility locus. Since many loci have been mapped for a given disease it is recommended that you select a single gene and review the methodology and evidence for its contribution to the disease.

Your discussion should include:
i. Consideration of the characteristics of the cohort of samples used for genetic analysis, e.g. family studies, ethnicity, disease phenotype, controls etc.;

ii. Discussion of mapping methodology linkage analysis, LOD score interpretation; selection of suitable markers, etc.;

iii. Fine mapping of the locus, and where possible identification of the disease allele;

iv. Other supporting evidence;

v. A brief assessment of further work that could provide more evidence linking the gene to the disease.

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